arcainnovАрктика и инновацииArctic and Innovations3034-1434ФГАОУ ВО «МАУ»10.21443/3034-1434-2024-2-2-68-81arcainnov-36Research ArticleСтатьиХарактеристика степени тяжести раннего формирования атеросклеротического процесса при отдельных патологических формах ишемической болезни сердца у морских специалистов в условиях Арктического регионаCharacteristics of the severity of the early formation of the atherosclerotic process in certain pathological forms of coronary heart disease in marine specialists in the conditions of the Arctic regionЗакревскийЮ. Н.ZakrevskyYu. N.

Закревский Юрий Николаевич — доктор медицинских наук, профессор кафедры безопасности жизнедеятельности

Мурманск

Yury N. Zakrevsky — Dr.Sci. (Medicine), Professor, Department of Civil Defense

Murmansk 

zakrevskiyun@mauniver.ruhttps://orcid.org/0000-0001-8077-6279ГерцевА. В.GertsevA. V.

Герцев Алексей Владимирович – кандидат медицинских наук, начальник терапевтического отделения

ID WоS: 35387856 ID Scopus: 57198810794 ID РИНЦ: 993090

Североморск

Alexei V. Gertsev – Cand.Sci. (Medicine), Head, Therapeutic Department 

ID WоS: 35387856 ID Scopus: 57198810794 D RSCI: 993090 

Severomorsk

starcom50@mail.ruФГАОУ ВО «Мурманский арктический университет»РоссияMurmansk Arctic UniversityRussian FederationФГКУ «1469 Военно-морской клинический госпиталь» Министерства обороны Российской ФедерацииРоссия1469 Naval Clinical Hospital, Ministry of Defence of the Russian FederationRussian Federation202416062024226881Copyright © Закревский Ю.Н., Герцев А.В., 20242024Закревский Ю.Н., Герцев А.В.Zakrevsky Y.N., Gertsev A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.arcainnov.ru/jour/article/view/36

Целью настоящей работы явилось исследование состояния показателей липидного обмена, специфических маркеров атеросклероза, морфологических изменений в магистральных артериях, а также парно связанных между собой показателей в структуре формирования атеросклеротического процесса при изолированном течении отдельных патологических форм (болевые/безболевые эпизоды ишемии миокарда) ишемической болезни сердца, протекающей с расстройствами аффективного спектра, у специалистов из группы плавсостава, проходящих службу в условиях Крайнего Севера. По результатам проведенного исследования установлено, что при безболевой форме ишемии миокарда имеет место большая частота встречаемости структурных изменений в срединной оболочке обоих общих сонных артерий, проявляющихся ремоделированием в сосудистом русле, формированием атеросклеротических бляшек и стенозирующего атеросклероза. Кроме того, у таких пациентов зарегистрированы нарастание проатерогенной активности, снижение уровня атеропротекторных маркеров, а также перестройка парно связанных между собой показателей в структуре звеньев формирования атеросклеротического процесса. При этом усугубление основного патологического процесса при хронической ишемической болезни сердца непосредственно опосредовано с полиморбидностью в течении имеющихся заболеваний.

The present work aims to study lipid balance, specifi markers of atherosclerosis, morphological changes in the main arteries, as well as paired indicators, in the formation of the atherosclerotic process in some non-comorbid pathological forms (painful/silent episodes of angina pectoris) of chronic coronary artery disease occurring with affective disorders in shipboard personnel serving in the Far North. The study revealed a higher incidence of structural changes in the medial sheath of both common carotid arteries in silent angina pectoris, which are manifested in vascular bed remodeling, formation of atherosclerotic plaques, and stenotic atherosclerosis. In addition, an increase in proatherogenic activity, suppression of antiatherogenic parameters, as well as more significant changes in the paired indicators of the atherosclerotic process were observed in such patients. The exacerbation of the main pathological process in chronic coronary artery disease can be attributed to the existing polymorbidity.

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The authors declare that there are no conflicts of interest present.