Characteristics of the severity of the early formation of the atherosclerotic process in certain pathological forms of coronary heart disease in marine specialists in the conditions of the Arctic region
https://doi.org/10.21443/3034-1434-2024-2-2-68-81
Abstract
The present work aims to study lipid balance, specifi markers of atherosclerosis, morphological changes in the main arteries, as well as paired indicators, in the formation of the atherosclerotic process in some non-comorbid pathological forms (painful/silent episodes of angina pectoris) of chronic coronary artery disease occurring with affective disorders in shipboard personnel serving in the Far North. The study revealed a higher incidence of structural changes in the medial sheath of both common carotid arteries in silent angina pectoris, which are manifested in vascular bed remodeling, formation of atherosclerotic plaques, and stenotic atherosclerosis. In addition, an increase in proatherogenic activity, suppression of antiatherogenic parameters, as well as more significant changes in the paired indicators of the atherosclerotic process were observed in such patients. The exacerbation of the main pathological process in chronic coronary artery disease can be attributed to the existing polymorbidity.
About the Authors
Yu. N. Zakrevsky
Murmansk Arctic University
Russian Federation
Russian Federation
Yury N. Zakrevsky — Dr.Sci. (Medicine), Professor, Department of Civil Defense
Murmansk
A. V. Gertsev
1469 Naval Clinical Hospital, Ministry of Defence of the Russian Federation
Russian Federation
Russian Federation
Alexei V. Gertsev – Cand.Sci. (Medicine), Head, Therapeutic Department
ID WоS: 35387856
ID Scopus: 57198810794
D RSCI: 993090
Severomorsk
References
1. Maslennikova G.Ya., Oganov R.G., Axelrod S.V., Boitsov S.A. Reducing mortality from cardiovascular and other non-communicable diseases in high-income economies: non-government involvement. Cardiovascular Therapy and Prevention. 2015;14(6):5–9. (In Russ.). https://doi.org/10.15829/1728-8800-2015-6-5-9
2. Meldekhanov T.T., Esirgepova S.R., Pirzhanov B.T., Elhendi T.N., Urazaeva M.T., Kabdygaliev E.A., Tabanova R.A., Elesheva K.K. pathogenesis of atherosclerosis. Actual Problems of Th oretical and Clinical Medicine. 2021;34(4):21–28. (In Russ.). https://doi.org/10.24412/2790-1289-2021-42128
3. Stupakov I.N., Gerber V.I. Cardiovascular morbidity among military personnel. Cardiovascular Therapy and Prevention. 2005;2(4):12–17. (In Russ.).
4. Fesenko V.V. Preventive medicine and a healthy lifestyle in the Armed Forces. Military Medical Journal. 2007;(7):24–32. (In Russ.).
5. Chumakova G.A., Gritsenko O.V., Veselovskaya N.G., Vakhromeeva E.V., Kozarenko A.A. Clinical significance of apolipoproteins A and B. Cardiovascular therapy and prevention. 2011;10(6):105–111. (In Russ.). https://doi.org/10.15829/1728-8800-2011-6-105-111
6. Baroni M.G., Berni A., Romeo S., Arca M., Tesorio T., Sorropago G., Di Mario U., Galton
7. D.J. Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD. BMC Med. Genet. 2003;4(8):1–7. https://doi.org/10.1186/1471-2350-4-8
8. Baygi F., Herttua K., Jensen O., Djalalinia S., Ghorabi A.M., Asayesh H., Qorbani M. Global prevalence of cardiometabolic risk factors in the military population: a systematic review and meta-analysis. BMC Endocr. Disord. 2020;20(1):8. https://doi.org/10.1186/s12902-020 0489-6
9. Boos C.J., De Villiers N., Dyball D., McConnell A., Bennett A.N. The Relationship between Military Combat and Cardiovascular Risk: A Systematic Review and Meta-Analysis. Int. J. Vasc. Med. 2019;2019: 9849465. https://doi.org/10.1155/2019/9849465
10. Brouillette C.G., Anantharamaiah G.M., Engler J.A., Borhani D.W. Structural models of human apolipoprotein A-I: critical analysis and review. Biochim. Biophys. Acta. 2001;1531(1-2):4– 46. https://doi.org/10.1016/s1388-1981(01)00081-6
11. Chetty P.S., Mayne L., Lund-Katz S., Stranz D., Englander S.W., Phillips M.C. Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry. Proc. Natl. Acad. Sci. USA. 2009;106(45):19005–19010. https://doi.org/10.1073/pnas.0909708106
12. Crum-Cianflone N.F., Bagnell M.E., Schaller E., Boyko E.J., Smith B., Maynard C., et al. Impact of combat deployment and posttraumatic stress disorder on newly reported coronary heart disease among US active duty and reserve forces. Circulation. 2014;129(18):1813–1820. https://doi.org/10.1161/CIRCULATIONAHA.113.005407
13. Dao-Quan Peng, Brubaker G., Zhiping Wu., Zheng L., Willard B., Kinter M., Hazen S.L., Smith J.D. Apolipoprotein A-I tryptophan substitution leads to resistance to myeloperoxidase mediated loss of function. Arterioscler. Thromb. Vasc. Biol. 2008;28(11):2063–2070. https://doi.org/10.1161/ATVBAHA.108.173815
14. Johnson A., Rose K, Elder G., Chambless L.E., Kaufman J.S., Heiss G. Military combat and risk of coronary heart disease and ischemic stroke in aging men: The Atherosclerosis Risk in Communities (ARIC) study. Ann. Epidemiol. 2010;20(2):143–150. https://doi.org/10.1016/j.annepidem.2009.10.006
15. Kyung-Hyun Cho, Jae-Ryong Kim. A reconstituted HDL containing V156K or R173C apoA-I exhibited anti-inflammatory activity in apo-E deficient mice and showed resistance to myeloperoxidase-mediated oxidation. Exp. Mol. Med. 2009;41(6):417–428. https://doi.org/10.3858/emm.2009.41.6.047
16. Mirzaeipour F., Seyedmazhari M., Pishgooie A., Hazaryan M. Assessment of risk factors for coronary artery disease in military personnel: A study from Iran. J. Family Med. Prim. Care. 2019;8(4):1347–1351. https://doi.org/10.4103/jfmpc.jfmpc_109_19
17. Parsons I., White S., Gill R. Gray H.H., Rees P. Сoronary artery disease in the military patient. J. R. Army Med. Corps. 2015;161(3):211–222. https://doi.org/10.1136/jramc-2015-000495
18. Richardson P.E., Manchekar M., Dashti N., Jones M.K., Beigneux A., Young S.G, et al. Assembly of Lipoprotein Particles Containing Apolipoprotein-B: Structural Model for the Nascent Lipoprotein Particle. Biophys. J. 2005;88(4):2789–2800. https://doi.org/10.1529/biophysj.104.046235
19. Ulmer C.S., Bosworth H.B., Germain A., Lindquist J., Olsen M., Brancu M., et al. VA MidAtlantic Mental Illness Research Education and Clinical Center Registry Workgroup, Beckham JC. Associations between sleep difficulties and risk factors for cardiovascular disease in veterans and active-duty military personnel of the Iraq and Afghanistan conflicts. J. Behav. Med. 2015;38(3):544–555. https://doi.org/10.1007/s10865-015-9627-4
Review
For citations:
Zakrevsky Yu.N., Gertsev A.V. Characteristics of the severity of the early formation of the atherosclerotic process in certain pathological forms of coronary heart disease in marine specialists in the conditions of the Arctic region. Arctic and Innovations. 2024;2(2):68-81. (In Russ.) https://doi.org/10.21443/3034-1434-2024-2-2-68-81
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